Coagulation Factor XIIa (Activated Hageman Factor) Inhibitor from Adult Schistosoma Mansoni

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  • Department of Zoology, University of Georgia, Athens, Georgia 30602

An inhibitory activity for the contact phase of the intrinsic coagulation pathway was demonstrated in an extract of adult Schistosoma mansoni. Inhibition is apparently specific for the enzymatic activation of Factor XI (pre-PTA) by Factor XIIa (activated Hageman factor). This phenomenon offers an explanation for the schistosomal evasive mechanism of the host contact hemostatic defense system.

Author Notes

Submitted as partial fulfillment for the degree of Ph.D. from the University of Georgia, Zoology Department.

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