Failure of Levamisole to Alter the Lepromin Reaction

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  • ALM Leprosy Atelier, Department of Pathology, University of Hawaii School of Medicine, Institut Médical Evangélique, Honolulu, Hawaii 96816

In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatous leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.

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