Comparison of two Geographic Strains of Leishmania Donovani by Resistance of Mice to Superinfection

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  • Department of Zoology and Bureau of Biological Research, Rutgers University, New Brunswick, New Jersey 08903

Groups of mice were injected with Leishmania donovani strains Et (Burma) or 1S (Sudan) and the courses of infection were followed. Between days 20 and 30 after infection the liver parasite burdens decreased, and the numbers of amastigotes were further reduced by treatment with pentostam. Et- and 1S-recovered mice were challenged by intravenous injection of amastigotes of each strain. Although resistance to superinfection was apparent the L. donovani strains could not be differentiated by this method.