Origin of Circulating Antigen from the Schistosome Gut

An Immunofluorescent Study

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  • Department of Pathology, Harvard Medical School-Peter Bent Brigham Hospital, Naval Medical Research Institute, Boston, Massachusetts 02115

Immunofluorescent staining of schistosome worms with specific anti-circulating schistosome antigen (CSA) rabbit immunoglobulin plus goat anti-rabbit immunoglobulin-fluorescein conjugate strongly suggests that the gut, and not the integument, is the site of production of circulating schistosome antigen. Plans for further studies of CSA and of its role in schistosomiasis are outlined.