Course of development of Leishmania enriettii infection in immunosuppressed guinea pigs

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  • 1 Stanford Research Institute, Menlo Park, California 94025

The course of development of L. enrietti infection in normal and immunosuppressed guinea pigs was studied. The leishmanial lesion in normal guinea pigs is confined and self-limiting, but in immunosuppressed animals it metastasizes and diffuses to various parts of the body, particularly the extremities. Successful immunosuppression for such studies can be achieved by administering antilymphocytic antiserum, cyclophosphamide, or whole-body irradiation. All such immunosuppressants must be continuously applied to lower the total white blood cell count to about 2.000/ml and maintain it at that level.

Author Notes

Address reprint requests to Dr. Lemma at his permanent address: Institute of Pathobiology, Haile Sellassie I University, Addis Ababa, Ethiopia.
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