Evaluation of Metronidazole and MK-910 in Invasive Amebiasis

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  • Amoebiasis Research Unit, Department of Medicine of the University of Natal, Durban, South Africa

Further trials of metronidazole in acute amebic dysentery have confirmed that a regimen of 800 mg thrice daily for 5 days is highly effective. Single daily doses of 2.0 g for 2 or 3 days produced similar results. In amebic liver abscess, 800 mg thrice daily for 5 days was effective both in curing the abscess and in eradicating Entamoeba histolytica from the bowel. Lower doses were less reliable in curing intestinal infection. In a series of trials of MK-910 in amebic dysentery and amebic liver abscess, at dosages up to 10 mg per kg of body weight daily for 5 days, the drug frequently did not eradicate E. histolytica from the bowel.

Author Notes

The Amoebiasis Research Unit is sponsored by the following bodies: The South African Research Council; The Natal Provincial Administration; The University of Natal; and The United States Public Health Service (Grant A1 09654-02).

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