Paromomycin sulfate (Humatin) was used to treat cestode infections in 28 patients. Eight patients with Taenia saginata, 3 with Taenia solium, and four with Diphyllobothrium latum infections were each successfully treated with a single 4-g dose administered over a 1-hour period for adults and a single dose of 75 mg per kg of body weight for children. Twelve of 13 patients with Hymenolepis nana infections were cured. 10 by the single 4-g dose, and 2 of 3 by the administration of 45 mg per kg of body weight over a period of 5 days. The apparent resistance of H. nana to the single-dose regimen is believed to be related to the low absorption of the antibiotic and the inaccessibility of the cysticercoids that are buried deep within the mucosa of the villi.
Career Scientist, Health Research Council, City of New York (I-450).