By Everard L. Napier, M.R.C.S., L.R.C.P. (Lond.). In charge Kala-azar research, Calcutta School of Tropical Medicine. Second edition. 185 pages of text with 15 charts in the text, 18 plates, and an appendix of references to literature, author index and subject index. Oxford University Press. London, Bombay, Calcutta, Madras, 1927
Sixty-two children infected with Ascaris lumbricoides were treated with a single dose (5 mg per pound) of pyrantel pamoate. Fifty-three (85.5%) were cured as judged by a negative, direct fecal smear and ZnSO4 concentrate one week after treatment. Egg counts were much reduced in the remaining positive cases. A 2-day regimen (5 mg per lb daily) cured 37 of 38 (97.4%) Ascaris-infected children. Forty-three patients with hookworm infections were given 5 mg per pound of pyrantel on 3 consecutive days. Cure was achieved in 36 (83.7%) patients. The drug produced only mild side-effects. The chief complaint was low-grade abdominal cramp during the time when the ascarids were being expelled. There were no abnormal changes in the urinalysis, SGOT, or the serum bilirubin levels after single- or triple-dose regimens.