Patterns of Viremia and Antibody Observed in Rhesus Monkeys Inoculated with Chikungunya and Other Serologically Related Group a Arboviruses

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  • Division of Veterinary Medicine, The Walter Reed Army Institute of Research, Washington, D. C. 20012
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The rhesus monkey is susceptible to experimental infection with chikungunya and Mayaro viruses as evidenced by a febrile reaction and high levels of circulating virus. These animals appeared refractory to infection with O'nyong-nyong virus. Infection with either Chikungunya or Mayaro virus protects these animals against infection with the heterologous virus. These results clearly show that the Asian rhesus monkey is a suitable laboratory animal for the serologic and immunologic study of selected group A arboviruses.

Author Notes

Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201.