Live, Attenuated Venezuelan Equine Encephalomyelitis Virus Vaccine

I. Clinical Effects in Man

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  • U. S. Army Medical Unit, Walter Reed Army Medical Center, Fort Detrick, Frederick, Maryland 21701


Forty young men were inoculated with live, attenuated VEE virus vaccine, and as evidenced by a significant increase in hemagglutination-inhibiting antibody titers, all were infected. However, viremia was demonstrated in only 13. The level of viremia was low, varied with time, and occurred between 60 hours and 12 days after vaccination. All subjects were evaluated closely from clinical, laboratory, virologic, and serologic standpoints. Some degree of reaction was seen in 37.5% of these persons, 10% of them having a 3+ reaction, of a possible 4+. Viremia was demonstrated in 32.5%. Transient electrocardiographic abnormalities were noted in 47.5%, and 40% had transient leukopenia. Eight men followed with daily electroencephalographic tracings demonstrated no significant change subsequent to vaccination. There was no consistent positive or negative correlation between any of these responses or combination of responses.

Author Notes

Present address: 1209 St. Paul Street, Baltimore, Maryland 21202.

Present address: Children's Service, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114.