Effects of Pyrimethamine, Chlorguanide, and Primaquine against Exoerythrocytic Forms of a Strain of Chloroquine-Resistant Plasmodium Falciparum from Thailand

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  • Army Medical Research Unit of the Department of Medicine, Division of the Biological Sciences, The University of Chicago, Chicago, Illinois


Studies to assess the potential causal prophylactic value of chlorguanide, pyrimethamine, and primaquine against a strain of chloroquine-resistant P. falciparum, the Thailand (JHK) strain, indicated that daily administration of chlorguanide, weekly administration of pyrimethamine, or weekly administration of primaquine may prove far from uniformly effective.

Author Notes

Present address: Departments of Medicine (Simpson Memorial Institute) and Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.