A Comparison of Oral and Parenteral Activity of Hycanthone and Lucanthone in Experimental Infections with Schistosoma Mansoni

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  • Sterling-Winthrop Research Institute, Rensselaer, New York


Hycanthone is the 4-hydroxymethyl analogue and the active metabolite of lucanthone. When administered intragastrically, hycanthone is nine times more active than lucanthone against Schistosoma mansoni (Puerto Rican strain) in experimentally infected hamsters, and three times more active than lucanthone in mice.

The schistosomicidal activity of a single intramuscular dose of hycanthone is equal to that obtained by a 5-day regimen of intragastric medication. Conversely, lucanthone is only slightly active parenterally at subtoxic levels.