The Evaluation of Quinine Sulfate and Diaminodiphenyl Sulfone (DDS) as Suppressive Agents against Sporozoite-Induced Chesson Strain Vivax Malaria

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  • Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia


The evaluation of quinine sulfate and diaminodiphenyl sulfone (DDS) as suppressants against sporozoite-induced Chesson strain Plasmodium vivax is reported. The results indicate that quinine sulfate, 7.5 grams daily, is inadequate to offer complete protection in that 3 of 4 volunteers developed patent infections. DDS, when given in daily doses of 25 mg, failed to protect 5 of 5 volunteers.

Author Notes

Cytology Section, LPC, NIAID, NIH, P.O. Box 190, Chamblee, Georgia.

Professor of Pharmacology, Louisiana State University Medical School, New Orleans, Louisiana.