A random sample of 19 Puerto Rican patients infected with Schistosoma mansoni were treated with a 40- to 80-mg dose of Astiban®/kg of body weight over periods ranging from 11 to 16 days. In spite of the high cure rate of 94%, the frequency and severity of the side effects do not justify the use of this massive dose in schistosomiasis chemotherapy.
Assistant Professor of Environmental Medicine and Community Health, Downstate Medical Center, State University of New York. Present address: 450 Clarkson Ave., Brooklyn, New York 11203.
Physician in Charge, Morrisania Tropical Disease Clinic, New York City Health Department.
Chief, Tropical Disease Division, New York City Health Department.
Physician in Charge, Washington Heights Tropical Disease Clinic, New York City Health Department.