Prophylactic and Curative Activities of Antimony (III) Dimercapto Succinic Acid in Olive Oil Suspension, Dicarbonic Acid Hydrazide, an Organic Phosphorus Compound (Ronnel®) and a Nitro-Thiazole Derivative in Rhesus Monkeys Experimentally Infected with Schistosoma Mansoni

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  • Department of Medical Zoology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012

Summary

A series of experiments was undertaken to evaluate the prophylactic, suppressive and therapeutic effects of four compounds against Schistosoma mansoni infections in rhesus monkeys. Marked therapeutic activity was obtained with an olive oil suspension of antimony dimercapto succinic acid in lower doses than those required for the sodium antimony dimercapto succinate in water. These results would suggest that sustained levels of antimony may result in enhanced schistosomicidal activity, thus permitting the use of smaller doses.

Anti-schistosomal action was also observed with two non-antimonial compounds. However, one of these, a dicarbonic acid hydrazide, was active only in large doses administered parenterally. Although quantities of eggs in the stools were greatly reduced, considerable numbers of live worms remained at necropsy. The nitro-thiazole derivative, however, manifested prophylactic, suppressive and curative effects in doses seemingly well tolerated. This was shown by a marked reduction in worm number, stunting of the few surviving worms, and by the virtual elimination of eggs in the stools. Female worms appeared to be much more susceptible to the drug than males, and egg laying was arrested even in the few surviving females.

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