Glucose-6-Phosphate Dehydrogenase Deficiency and Falciparum Malaria

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  • Army Medical Research Unit of the Department of Medicine, the Division of Biological Sciences, University of Chicago, Chicago, Illinois


Investigations of the duration of the prepatent period and of the early clinical course of falciparum malaria (McLendon strain) were conducted with 16 non-immune American Negro men. Eight of the men were glucose-6-phosphate dehydrogenase (G6PD)-deficient and 8 were not. The investigations did not disclose evidence supporting the hypothesis that G6PD deficiency confers a biologic advantage against falciparum malaria.