Fluorescent Antibody Studies in Human Malaria

III. Development of Antibodies to Plasmodium Falciparum in Semi-immune Patients

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  • National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Cytology, P.O. Box 190, Chamblee, Georgia
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Using the indirect fluorescent antibody (FA) method, the production of antibody to Plasmodium falciparum was demonstrated in eight patients having prior experience with strains of the parasite.

The FA endpoints rose rapidly to levels much higher than had been reported for patients who had had no previous experience with P. falciparum.

In two patients, the FA response was such that it was possible to differentiate between endpoints to the Colombia and Thailand strains of P. falciparum.

Author Notes

Present address: Assistant Chief, Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.