The Serological Reactions in a Case of Rift Valley Fever

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  • Department of Hazardous Operations, Walter Reed Army Institute of Research, Department of Medicine, School of Medicine, University of Maryland, Washington 12, D. C.


The neutralizing (N), hemagglutination-inhibition (HI), and complement-fixation (CF) antibody responses following a laboratory infection with Rift Valley fever (RVF) virus in an individual have been determined. Neutralizing, HI, and CF antibodies persisted for the 18-month period of observation for which the individual was available. The advantages in economy and time required to perform HI and CF tests over the N test would be of particular value where serological cross-reactions do not occur, for example RVF.

Following inoculation of 2 cynomolgus monkeys with 106 mouse LD50 of pantropic RVF virus, the persistence of N, HI, and CF antibodies was observed for a 4-month period.

Author Notes

Present address: National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.