The Suppressive Activity of Sodium Antimony Dimercaptosuccinate (TWSB) in Experimental Infections with Schistosoma Mansoni

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  • Department of Medical Zoology, Walter Reed Army Medical Center, Walter Reed Army Institute of Research, Washington 12, D.C.


Intramuscular injections of sodium antimony dimercapto-succinate (TWSb) into Macaca mulatta monkeys, experimentally infected with Schistosoma mansoni, resulted in suppressing the passage of eggs in their feces.

Temporary suppression was obtained with a single dose of the drug or by three doses given 2 weeks apart. Three injections of the drug given 3 weeks apart or five injections at 2-week intervals practically eliminated eggs from the monkeys' stools and greatly reduced the number of worms recovered at necropsy. Symptoms of drug toxicity were not observed in any of the animals.