By H. J. Bensted, W. Bulloch, L. Dudgeon, A. G. Gardner, E. D. W. Greig, D. Harvey, W. F. Harvey, T. J. Mackie, R. A. O'Brien, H. M. Perry, H. Scutze, P. Bruce White, W. J. Wilson. London, 1929. His Majesty's Stationery Office. Pp. 1–482
by A. Trevor Willis, M.D., B.S. (Melb.), Ph.D. (Leeds), M.C.Path., M.C.P.A., Reader in Microbiology, Monash University, formerly Lecturer in Bacteriology, University of Leeds. xiv + 234 pages, illustrated, second edition. Butterworth Inc., Washington. 1965. $8.50
Intramuscular injections of sodium antimony dimercapto-succinate (TWSb) into Macaca mulatta monkeys, experimentally infected with Schistosoma mansoni, resulted in suppressing the passage of eggs in their feces.
Temporary suppression was obtained with a single dose of the drug or by three doses given 2 weeks apart. Three injections of the drug given 3 weeks apart or five injections at 2-week intervals practically eliminated eggs from the monkeys' stools and greatly reduced the number of worms recovered at necropsy. Symptoms of drug toxicity were not observed in any of the animals.