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Case Report: Coral Reef Pathogen Aspergillus sydowii Causing Black Grain Mycetoma

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  • 1 Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México;
  • 2 Rheumatology Department, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México

ABSTRACT

Mycetoma is an infrequent subcutaneous infection caused by true fungi (eumycetoma) or aerobic actinomycetes (actinomycetoma). We report the case of a 62-year-old man with eumycetoma involving the left foot and ankle. Skin biopsy revealed black-brown grains, and in culture, a white colony fungus grew at day 8. Molecular sequencing using ITS1-ITS4 primers identified the species as Aspergillus sydowii. The patient was treated with itraconazole 200 mg twice daily and terbinafine 250 mg daily for 8 months, with complete response and no recurrence after 2.5 years of follow-up. Aspergillus sydowii is a saprotrophic fungus that rarely causes skin or nail disease. No cases of eumycetoma caused by this agent have been previously reported. As its geographic distribution continues to expand, it may increasingly be recognized as a cause of human disease.

Author Notes

Address correspondence to Lucio Vera-Cabrera, Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Av. Gonzalitos No. 235 Nte., Col. Mitras Centro, Monterrey 64460, Mexico. E-mail: luvera_99@yahoo.com

Authors’ addresses: Lucio Vera-Cabrera, Adrian Cuellar-Barboza, Anabel Gallardo-Rocha, Carmen Amelia Molina-Torres, Wendy Escalante-Fuentes, and Jorge Ocampo-Candiani, Department of Dermatology, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico, E-mails: luvera_99@yahoo.com, abcuellar89@gmail.com, anabelgrocha@yahoo.com, carmelia7@hotmail.com, wendyescalante64@hotmail.com, and jocampo2000@yahoo.com.mx. Jesus Alberto Cardenas-de la Garza, Department of Rheumatology, Hospital Universitario Dr. José Eleuterio González, Monterrey, Mexico, E-mail: cardenasdelagarza@gmail.com.

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