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Case Report: Successful Treatment of Pulmonary Talaromyces marneffei Infection with Posaconazole in a Renal Transplant Recipient

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  • 1 Department of Pulmonary and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China;
  • 2 Department of Imaging Institute, Cleveland Clinic, Cleveland, Ohio;
  • 3 Department of Radiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China

ABSTRACT

Talaromyces marneffei (T. marneffei), formerly Penicillium marneffei, is a dimorphic fungus prevalent in Southeast Asia that can cause severe systemic infection, especially in immunocompromised patients. There are few reports about the use of posaconazole in T. marneffei infection. Here, we present a case of pulmonary T. marneffei infection in a renal transplant recipient. The patient responded rapidly to oral posaconazole administration but experienced serum creatinine fluctuation because of the interaction between posaconazole and immunosuppressants. Seven months after adjusting the dose of immunosuppressants, the patient recovered completely. Posaconazole is a potentially promising therapy for T. marneffei infection, but it should be administered under close monitoring.

Author Notes

Address correspondence to Hai-Ying Yan, Department of Pulmonary and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, No. 32, West Section 2, Ring Rd., Qingyang District, Chengdu 610072, China. E-mail: yanhaiying@med.uestc.edu.cn

Disclosure: All data generated or analyzed during this study are included in this published article. This study was approved by the Ethics Committee of Sichuan Provincial People’s Hospital (number 2020145). Written informed consent was obtained from the patient. Q. L. performed conception and design, data collection, data analysis and interpretation, and drafting the article; H.-Y. Y. provided materials and samples; A. C. and W.-F. K. performed image analysis; H.-Y. Y. provided administrative support.

Authors’ addresses: Qin Lang and Hai-Ying Yan, Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China, E-mails: langqin@med.uestc.edu.cn and yanhaiying@med.uestc.edu.cn. Aamer Chughtai, Department of Imaging Institute, Cleveland Clinic, Cleveland, OH, E-mail: aamerchughtai100@gmail.com. Wei-Fang Kong, Department of Radiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China, E-mail: 13936034@qq.com.

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