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Case Report: Gestational Melioidosis through Perinatal Transmission

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  • 1 Centro de Investigaciones Microbiológicas del Cesar (CIMCE), Valledupar, Colombia;
  • 2 Clínica Laura Daniela, Valledupar, Colombia;
  • 3 Facultad de Medicina, Universidad El Bosque, Bogotá, Colombia;
  • 4 Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia;
  • 5 Facultad de Medicina, Universidad del Norte, Barranquilla, Colombia;
  • 6 Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia;
  • 7 Clínica Colsanitas, Clínica Universitaria Colombia, Bogotá, Colombia

ABSTRACT

Burkholderia pseudomallei is an emerging pathogen in the Americas. Cases of mother-to-child transmission of B. pseudomallei are rare and probably occur by placental or perinatal infection. We report the first case of native gestational and neonatal melioidosis in the Western hemisphere. The isolated strains in the mother and newborn were confirmed by whole-genome sequencing and identified as a novel sequence type ST1748. The comparison of both genomes revealed a nucleotide similarity of 100%. Melioidosis should be considered within the differential diagnosis of febrile illness or pneumonia in pregnant women and newborns from endemic areas of the Americas.

Author Notes

Address correspondence to José Y. Rodríguez, Centro de Investigaciones Microbiológicas del Cesar CIMCE, Calle 16 C No. 19 D 14, Valledupar Cesar, Valledupar, Colombia 200004, E-mail: jyrodriguezq@gmail.com or Mónica G. Huertas, Molecular Genetics and Antimicrobial Resistance Unit, Faculty of Medicine, Universidad El Bosque, Av. Cra. 9, No. 131 A – 02, Bogotá, Colombia 110121, E-mail: huertasmonica@unbosque.edu.co.

Financial support: This work was funded by Universidad El Bosque (Grant No. PCI-2018-10191).

Authors’ addresses: José Y. Rodríguez, Infectologia, Centro de Investigaciones Microbiológicas del Cesar (CIMCE), Valledupar, Colombia, and Infectologia, Clínica Laura Daniela, Valledupar, Colombia, E-mail: jyrodriguezq@gmail.com. Mónica G. Huertas, Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia, E-mail: huertasmonica@unbosque.edu.co. Gerson J. Rodríguez, Infectologia, Centro de Investigaciones Microbiológicas del Cesar (CIMCE), Valledupar, Colombia, and Facultad de Medicina, Universidad del Norte, Barranquilla, Colombia, E-mail: grodryq@gmail.com. Sandra Vargas-Otalora, Rafael Rios, Lorena Diaz, and Jinnethe Reyes, Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia, E-mails: vsandra@unbosque.edu.co, rriosn@unbosque.edu.co, diazsandra@unbosque.edu.co, and reyesjinnethe@unbosque.edu.co. Miguel A. Benıtez-Peñuela, Infectologia, Centro de Investigaciones Microbiológicas del Cesar (CIMCE), Valledupar, Colombia, E-mail: miguelbenitez0128@gmail.com. Kelin Esquea, Infectologia, Clínica Laura Daniela, Valledupar, Colombia, E-mail: kelinrox0420@hotmail.com. Laura R. Mendoza, Infectologia, Clínica Laura Daniela, Valledupar, Colombia, and Facultad de Medicina, Universidad del Norte, Barranquilla, Colombia, E-mail: lrmendoza@uninorte.edu.co. Carlos A. Álvarez-Moreno, Departamento de Medicina Interna, Universidad Nacional de Colombia, Bogotá, Colombia, and Infectologia, Clínica Colsanitas, Clínica Universitaria Colombia, Bogotá, Colombia, E-mail: calvarem@gmail.com.

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