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    Oral manifestation. (A) Oral findings on day 4 of the illness showing spotted submucosal hemorrhages on the hard palate (arrow) and rose-colored spots on the soft palate (arrow head). (B) Oral findings on day 7 of the illness showing spotted submucosal hemorrhages on the hard palate only.

  • 1.

    Chadwick D, Arch B, Wilder-Smith A, Paton N, 2006. Distinguishing dengue fever from other infections on the basis of simple clinical and laboratory features: application of logistic regression analysis. J Clin Virol 35: 147153.

    • Search Google Scholar
    • Export Citation
  • 2.

    Thomas EA, John M, Bhatia A, 2007. Cutaneous manifestations of dengue viral infection in Punjab (north India). Int J Dermatol 46: 715719.

  • 3.

    Ali Azfar Senior Registrar N, Ali Azfar N, Mahmood Malik L, Jamil A, Jahangir M, Tirmizi N, Majid A, Ashraf M, Malik M, 2012. Cutaneous manifestations in patients of dengue fever. J Pakistan Assoc Dermatologists 22: 320324.

    • Search Google Scholar
    • Export Citation
  • 4.

    Sheikh KR, Shehzad A, Mufti S, Mirza UA, Shamsuddin, 2012. Skin involvement in patients of dengue fever during the 2011 epidemic in Lahore, Pakistan. J Pakistan Assoc Dermatologists 22: 325330.

    • Search Google Scholar
    • Export Citation
  • 5.

    Siler JF, Hall MW, Hitchens AP. 1926. Dengue: its history, epidemiology, mechanism of transmission, etiology, clinical manifestations, immunity, and prevention. Philipp J Sci 29: 1304.

    • Search Google Scholar
    • Export Citation
  • 6.

    Forchheimer F, 1898. The enanthem of German measles. Philadelphia Med J 11: 1516.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Oral Manifestation Like Forchheimer Spots of Dengue Fever

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  • 1 Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan

A 6-year-old boy of a mixed Japanese and Caucasian origin complained of a 4-day history of fever, cough, and blepharedema in 2014. He had a medical history of bronchial asthma and attention-deficit/hyperactivity disorder treated by methylphenidate. Blood test results showed a mild decrease in white blood cell (1,990/µL) and thrombocyte counts (9.6 × 104/µL) without liver and kidney dysfunction. Dengue NS1 antigen was tested, and the results were positive. The serotype of dengue virus was type 1. The patient had no history of travel abroad in the last 2 weeks; however, an outbreak of dengue fever occurred in 2014 in Japan. He had spotted submucosal hemorrhages on the hard palate (Figure 1A, arrow) and rose-colored spots on the soft palate (Figure 1A, arrow head). Later, his fever receded, and a diffuse rash appeared on day 6 of the illness without severe complications. The rose-colored spots improved on day 7 of the illness (Figure 1B). Furthermore, he did not show any symptoms specific to rubella, measles, and scarlet fever, which occasionally involve the appearance of Forschheimer spots. Except for submucosal hemorrhages, oral manifestations of dengue infection were not common (less than 10%),1,2 but some authors reported as common findings (14–43%)3,4 as diffuse mucosal erythema or mucosal involvement. Moreover, Siler et al.5 reported that 19% of dengue fever patients produced experimentally by bites of infected mosquitoes had congestion of throat. However, the red spots on the soft palate such as Forchheimer spots6 have not been reported in the literature.

Figure 1.
Figure 1.

Oral manifestation. (A) Oral findings on day 4 of the illness showing spotted submucosal hemorrhages on the hard palate (arrow) and rose-colored spots on the soft palate (arrow head). (B) Oral findings on day 7 of the illness showing spotted submucosal hemorrhages on the hard palate only.

Citation: The American Journal of Tropical Medicine and Hygiene 101, 4; 10.4269/ajtmh.19-0338

REFERENCES

  • 1.

    Chadwick D, Arch B, Wilder-Smith A, Paton N, 2006. Distinguishing dengue fever from other infections on the basis of simple clinical and laboratory features: application of logistic regression analysis. J Clin Virol 35: 147153.

    • Search Google Scholar
    • Export Citation
  • 2.

    Thomas EA, John M, Bhatia A, 2007. Cutaneous manifestations of dengue viral infection in Punjab (north India). Int J Dermatol 46: 715719.

  • 3.

    Ali Azfar Senior Registrar N, Ali Azfar N, Mahmood Malik L, Jamil A, Jahangir M, Tirmizi N, Majid A, Ashraf M, Malik M, 2012. Cutaneous manifestations in patients of dengue fever. J Pakistan Assoc Dermatologists 22: 320324.

    • Search Google Scholar
    • Export Citation
  • 4.

    Sheikh KR, Shehzad A, Mufti S, Mirza UA, Shamsuddin, 2012. Skin involvement in patients of dengue fever during the 2011 epidemic in Lahore, Pakistan. J Pakistan Assoc Dermatologists 22: 325330.

    • Search Google Scholar
    • Export Citation
  • 5.

    Siler JF, Hall MW, Hitchens AP. 1926. Dengue: its history, epidemiology, mechanism of transmission, etiology, clinical manifestations, immunity, and prevention. Philipp J Sci 29: 1304.

    • Search Google Scholar
    • Export Citation
  • 6.

    Forchheimer F, 1898. The enanthem of German measles. Philadelphia Med J 11: 1516.

Author Notes

Address correspondence to Kei Yamamoto, Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. E-mail: kyamamoto@hosp.ncgm.go.jp

Author’s address: Kei Yamamoto, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan, E-mail: kyamamoto@hosp.ncgm.go.jp.

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