This study deals with the compound CI-423 [3-chloro-9(4-diethylamino-1-methylbutylamino) acridine, 10-oxide, dihydrochloride] as a potential non-staining, suppressive antimalarial drug.
Comparative testing by the drug-diet method against trophozoite-induced Plasmodium lophurae infections in chicks indicated CI-423 to be approximately 16 times as active as quinine, 4 times as active as quinacrine, and one-half as active as amodiaquin.
Comparisons on a single or multiple oral dose basis against trophozoite-induced Plasmodium cynomolgi infections in rhesus monkeys showed CI-423 to be distinctly more potent than either amodiaquin or quinacrine in rapidly suppressing the acute parasitemia and curing the animals.
In contrast to quinacrine, CI-423 did not induce visible staining of the skin of mice or rats when given for respective periods of 2 and 4 weeks.
Present address: University of Texas Medical Branch, Galveston, Texas.