Volume 77, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


In May 2005, a cluster of four hantavirus pulmonary syndrome (HPS) cases was confirmed in Alberta, Canada. The cluster is unusual given that three cases were from a single family and involved a 7-year-old child. This is the first family cluster reported in Canada and includes one of the youngest cases of HPS reported in North America.


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  1. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 : 914–917. [Google Scholar]
  2. Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR, Ksiazek TG, Rollin PE, Nichol S, Umland ET, Moolenaar RL, Reef SE, Nolte KB, Gallaher MM, Butler JC, Breiman RF, 1994. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. N Engl J Med 330 : 949–1005. [Google Scholar]
  3. Miedzinski L, 2005. Community-acquired pneumonia: new facets of an old disease—Hantavirus pulmonary syndrome. Respir Care Clin 11 : 45–58. [Google Scholar]
  4. Thacker SB, Wetterhall SF, 1997. Case definitions for infectious conditions under public health surveillance. MMWR Recomm Rep 46 : 16. [Google Scholar]
  5. Padula PJ, Colavecchia SB, Martinez VP, Gonzalez Della Valle MO, Edelstein A, Miguel SDL, Russi J, Mora Riquelme J, Colucci N, Almiron M, Rabinovich RD, 2000. Genetic diversity, distribution and serologic features of hantavirus infection in five countries in South America. J Clin Microbiol 38 : 3029–3035. [Google Scholar]
  6. Pini NC, Resa A, del Jesus Laime G, Lecot G, Ksiazek TG, Levis S, Enria DA, 1998. Hantavirus infection in children in Argentina. Emerg Infect Dis 4 : 1–3. [Google Scholar]
  7. Overturf GD, 2005. Clinical Sin Nombre hantaviral infections in children. Pediatr Infect Dis J 24 : 373–374. [Google Scholar]
  8. Ramos MM, Overturf GD, Crowley MR, Rosenberg RB, Hjelle B, 2001. Infection with Sin Nombre hantavirus: clinical presentation and outcome in children and adolescents. Pediatrics 108 : 1–6. [Google Scholar]
  9. Centers for Disease Control and Prevention, 2006. Case information: Hantavirus pulmonary syndrome case count and descriptive statistics. Available at www.cdc.gov/ncidod/diseases/hanta/hps/noframes/caseinfo.htm. Accessed May 16, 2006.
  10. Ferres M, Vial P, 2004. Hantavirus infection in children. Curr Opin Pediatr 16 : 70–75. [Google Scholar]
  11. Lee BE, Joffe AR, Vaudry W, 1998. Hantavirus pulmonary syndrome: report of the first Canadian paediatric case. Can J Infect Dis 9 : 319–321. [Google Scholar]
  12. Ksiazek TG, Peters JC, Rollin PE, Zaki SR, Nichol S, Spiropoulou C, Morzunov S, Feldmann H, Sanchez A, Khan AS, Mahy BWJ, Wachsmuth K, Butler J, 1995. Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 52 : 117–123. [Google Scholar]
  13. Armstrong LR, Bryan RT, Sarisky J, Khan AS, Rowe T, Ettestad PJ, Cheek JE, Peters CJ, Rollin P, Martin ML, Ksiazek TG, 1995. Mild hantaviral disease caused by Sin Nombre virus in a four-year-old child. Pediatr Infect Dis J 14 : 1108–1110. [Google Scholar]
  14. Allen S, Feddersen R, Foucar K, Hjelle B, James D, Jenison S, Koster F, Levy H, Mertz G, Simpson S, Williams J, Nolte K, Sewell CM, Sands L, Rutherford GW, Hoffman RE, Dixon FR, McFarland L, Damrow TA, DiSalvo A, Shireley LA, Fleming D, Senger KA, Simpson DM, Nichols CR, 1993. Outbreak of hantavirus infection—Southwestern United States 1993. MMWR Morb Mortal Wkly Rep 42 : 477–479. [Google Scholar]
  15. Lindsay LR, Drebot MA, Weiss E, Artsob H, 2001. Hantavirus pulmonary syndrome in Manitoba. Can J Infect Dis 12 : 169–173. [Google Scholar]
  16. Martinez VP, Bellomo C, Juan JS, Pinna D, Forlenza R, Elder M, Padula PJ, 2005. Person-to-person transmission of Andes virus. Emerg Infect Dis 11 : 1848–1853. [Google Scholar]
  17. Lazaro ME, Cantoni GE, Calanni LM, Resa AJ, Herrero ER, Iacono MA, Enria DA, Cappa SMG, 2007. Clusters of hantavirus infection, southern Argentina. Emerg Infect Dis 13 : 104–110. [Google Scholar]
  18. Wells RM, Estani SS, Yadon ZE, Enria D, Padula P, Pini N, Mills JN, Peters CJ, Segura EL, 1997. An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Emerg Infect Dis 3 : 171–174. [Google Scholar]
  19. Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD, 1998. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241 : 323–330. [Google Scholar]
  20. Verity R, Prasad E, Grimsrud K, Artsob H, Drebot M, Miedzinski L, Preiksaitis J, 2000. Hantavirus pulmonary syndrome in northern Alberta, Canada: clinical and laboratory findings for 19 cases. Clin Infect Dis 31 : 942–946. [Google Scholar]
  21. Engelthaler DM, Mosley DG, Cheek JE, Levy CE, Komatsu KK, Ettestad P, Davis T, Tanda DT, Miller L, Frampton JW, Porter R, Bryan RT, 1999. Climatic and environmental patterns associated with hantavirus pulmonary syndrome cases in the four corners region. Emerg Infect Dis 5 : 87–94. [Google Scholar]
  22. Mertz GJ, Hjelle BL, Bryan RT, 1997. Hantavirus infection. Adv Intern Med 42 : 369–421. [Google Scholar]

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  • Received : 08 Dec 2006
  • Accepted : 22 Jul 2007

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