Volume 75, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Malarone was compared with placebo in a double-blind, randomized, placebo-controlled trial of prophylaxis of malaria in predominately areas of Colombia. The study population consisted of 180 completely non-immune Colombian soldiers, male, average age 19 years, and average weight 63 kg. Twenty-four subjects were considered unevaluable because of compliance issues, including one Malarone subject (with no detectable drug levels) who became infected with Of the 97 evaluable subjects who received Malarone (250 mg atovaquone plus 100 mg proguanil hydrochloride) daily from 1 day before entering the endemic area to 7 days after leaving the endemic area, none became parasitemic. Of the 46 evaluable placebo subjects, 11 became infected with and 2 became infected with . The protective efficacy of Malarone for all malaria and for malaria was 100% (LL 95% CI = 63%) and 100% (LL 95% CI = 58%), respectively, and was 96% if the one case with undetectable blood levels was included. Malarone has high protective efficacy for in Colombia.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Alves FP, Durlacher RR, Menezes MJ, Krieger H, Silva LH, Camargo EP, 2002. High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations. Am J Trop Med Hyg 66 : 641–648. [Google Scholar]
  2. Kayentao K, Kodio M, Newman RD, Maiga H, Doumtabe D, Ongoiba A, Coulibaly D, Keita AS, Maiga B, Mungai M, Parise ME, Doumbo O, 2005. Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali. J Infect Dis 191 : 109–116. [Google Scholar]
  3. Schellenberg D, Menendez C, Aponte JJ, Kahigwa E, Tanner M, Mshinda H, Alonso P, 2005. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365 : 1481–1483. [Google Scholar]
  4. Marra F, Salzman JR, Ensom MH, 2003. Atovaquone-proguanil for prophylaxis and treatment of malaria. Ann Pharmacother 37 : 1266–1275. [Google Scholar]
  5. Anonymous, 2004. Malarone. Physicians Desk Ref 58 : 1567–1570. [Google Scholar]
  6. Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, Joubert I, Klein KC, Shaw D, Roskell NS, Chulay JD, Malarone International Study, 2000. Atovaquone/ proguanil versus chloroquine/proguanil for malaria prophylaxis in non-immune travellers: Results from a randomized, double blind study. Lancet 356 : 1888–1894. [Google Scholar]
  7. Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, Toovey S, Knobloch J, Nothdurft HD, Shaw D, Roskell NS, Chulay JD, Malarone International Study Team, 2001. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study. Clin Infect Dis 33 : 1015–1021. [Google Scholar]
  8. Camus D, Djossou F, Schilthuis HJ, Hogh B, Dutoit E, Malvy D, Roskell NS, Hedgley C, De Boever EH, Miller GB, International Malarone Study Team, 2004. Atovaquone-proguanil versus chloroquine-proguanil for malaria prphylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study. Clin Infect Dis 38 : 1716–1723. [Google Scholar]
  9. Ling J, Baird JK, Fryauff DJ, Sismadi P, Bangs MJ, Lacy M, Barcus MJ, Gramzinski R, Maguire JD, Kumusumangsih M, Miller GB, Jones TR, Chulay JD, Hoffman SL, 2002. Naval Medical Research Unit 2 Clinical Trial Team. Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia. Clin Infect Dis 35 : 825–833. [Google Scholar]
  10. Mendis K, Sina BJ, Marchesini P, Carter R, 2001. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64 (Suppl 12): 97–106. [Google Scholar]
  11. Looareesuwan S, Wilairatana P, Glanarongran R, Indravijit KA, Supeeranontha L, Chinnapha S, Scott TR, Chulay JD, 1999. Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand. Trans R Soc Trop Med Hyg 93 : 637–640. [Google Scholar]
  12. Soto J, Toledo J, Rodriquez M, Sanchez J, Herrera R, Padilla J, Berman J, 1998. Primaquine prophylaxis against malaria in non-immune Colombian soldiers: Efficacy and toxicity. Ann Intern Med 129 : 241–244. [Google Scholar]
  13. Soto J, Toledo J, Rodriquez M, Sanchez J, Herrera R, Padilla J, Berman J, 1999. Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in non-immune Colombian soldiers. Clin Infect Dis 29 : 199–201. [Google Scholar]

Data & Media loading...

  • Received : 13 Feb 2006
  • Accepted : 13 Apr 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error