Volume 104, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



COVID-19 is an infectious disease caused by SARS-CoV-2. This enveloped RNA coronavirus primarily has tropism for the respiratory tract. However, it has also been shown to have various extrapulmonary manifestations such as pulmonary embolism, ischemic strokes, deep venous thrombosis, or arterial thrombosis. We present a case of a 34-year-old woman who had severe COVID-19 infection with no respiratory symptoms and developed strokes in multiple vascular territories and digital ischemia due to thrombosis formation in the brachial circulation of her arm despite receiving therapeutic anticoagulation.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. Wei-jie G et al., 2020. Clinical characteristics of coronavirus disease 2019 in China. New Engl J Med 382: 17081720.
    [Google Scholar]
  2. Oxley TJ et al., 2020. Large-vessel stroke as a presenting feature of COVID-19 in the young. New Engl J Med 382: e60.
    [Google Scholar]
  3. Ntaios G et al., 2020. Characteristics and outcomes in patients with COVID-19 and acute ischemic stroke. Stroke 51: e254e258.
    [Google Scholar]
  4. Merkler AE et al., 2020. Risk of ischemic stroke in patients with COVID-19 versus patients with influenza. J Am Med Assoc Neurol 77: 17.
    [Google Scholar]
  5. Zhang Y et al., 2020. Coagulopathy and antiphospholipid antibodies in patients with COVID-19. New Engl J Med 382: e38.
    [Google Scholar]
  6. Wichmann D et al., 2020. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med 173: 268277.
    [Google Scholar]
  7. Labo N, Ohnuki H, Tosato G, 2020. Vasculopathy and coagulopathy associated with SARS-CoV-2 infection. Cells 9: 1583.
    [Google Scholar]
  8. Klok FA et al., 2020. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 191: 145147.
    [Google Scholar]
  9. Ling L, Lu L, Cao W, Li T, 2020. Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect 9: 727732.
    [Google Scholar]
  10. Rico-Mesa JS, Rosas D, Ahmadian-Tehrani A, White A, Anderson A, Chilton R, 2020. The role of anticoagulation in COVID-19-induced hypercoagulability. Curr Cardiol Rep 22: 53.
    [Google Scholar]

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  • Received : 28 Aug 2020
  • Accepted : 08 Nov 2020
  • Published online : 17 Nov 2020
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