1921
Volume 102, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

(MAF) is known to endemically cause up to 40–50% of all pulmonary TB in West Africa. The aim of this study was to compare MAF with (MTB) with regard to time from symptom onset to TB diagnosis, and clinical and radiological characteristics. A cross-sectional study was conducted in Bamako, Mali, between August 2014 and July 2016. Seventy-seven newly diagnosed pulmonary TB patients who were naive to treatment were enrolled at Mali’s University Clinical Research Center. Sputum cultures were performed to confirm the diagnosis and spoligotyping to identify the mycobacterial strain. Univariate and multivariate analyses were used to identify factors associated with disease progression. Overall, the frequency of female patients was 25% in MAF infection and only 10.0% in MTB infection (OR = 2.9), and MAF was more represented in patients aged ≥ 30 years (57.1% versus 36.7% [OR = 2.3]). More MAF- than MTB-infected patients had a history of a prior TB contact (32.1% versus 14.3% [OR = 2.8]). The mean duration between cough onset and TB diagnosis was 111 days (∼3.7 months) for MAF and 72 days (∼2.4 months) for MTB ( = 0.007). In a multivariate regression, weight loss (body mass index [BMI] < 18.5 kg/m) and cough duration (> 4 months) were strongly associated with MAF infection (OR = 5.20 [1.49–18.26], = 0.010, and 4.74 [1.2–18.58], = 0.02), respectively. Our data show that MAF infection was significantly associated with lower BMI and a longer time between symptom onset and TB diagnosis than MTB. This supports the concept that MAF infection may have slower disease progression and less severe cough symptoms than MTB.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.19-0264
2019-11-11
2020-12-02
Loading full text...

Full text loading...

/deliver/fulltext/14761645/102/1/tpmd190264.html?itemId=/content/journals/10.4269/ajtmh.19-0264&mimeType=html&fmt=ahah

References

  1. de Jong BC, Hill PC, Aiken A, Jeffries DJ, Onipede A, Small PM, Adegbola RA, Corrah TP, 2007. Clinical presentation and outcome of tuberculosis patients infected by M. africanum versus M. tuberculosis. Int J Tuberc Lung Dis 11: 450456.
    [Google Scholar]
  2. de Jong BC, Antonio M, Gagneux S, 2010. Mycobacterium africanum–review of an important cause of human tuberculosis in west Africa. PLoS Negl Trop Dis 4: e744.
    [Google Scholar]
  3. Yeboah-Manu D, de Jong BC, Gehre F, 2017. The biology and epidemiology of Mycobacterium africanum. Adv Exp Med Biol 1019: 117133.
    [Google Scholar]
  4. Asante-Poku A et al., 2016. Molecular epidemiology of Mycobacterium africanum in Ghana. BMC Infect Dis 16: 385.
    [Google Scholar]
  5. de Jong BC, Adetifa I, Walther B, Hill PC, Antonio M, Ota M, Adegbola RA, 2010. Differences between TB cases infected with M. africanum, west-African type 2, relative to Euro-American M. tuberculosis–an update. FEMS Immunol Med Microbiol 58: 102105.
    [Google Scholar]
  6. Ejo M et al., 2015. First insights into circulating Mycobacterium tuberculosis complex lineages and drug resistance in Guinea. Infect Genet Evol 33: 314319.
    [Google Scholar]
  7. Gomgnimbou MK, Refrégier G, Diagbouga SP, Adama S, Kaboré A, Ouiminga A, Sola C, 2012. Spoligotyping of Mycobacterium africanum, Burkina Faso. Emerg Infect Dis 18: 117119.
    [Google Scholar]
  8. Tatiana OA, Francioli KK, Blanche MF, Romaric AG, Magloire T, Roger SM, Annie NNR, Francois-Xavier E, 2018. Is Mycobacterium africanum constitute a public health problem in douala: the most cosmopolite town of Cameroon. J Mol Microbiol 2.
    [Google Scholar]
  9. Diarra B et al., 2018. Mycobacterium africanum (lineage 6) shows slower sputum smear conversion on tuberculosis treatment than Mycobacterium tuberculosis (lineage 4) in Bamako, Mali. PLoS One 13: e0208603.
    [Google Scholar]
  10. Togo ACG et al., 2017. The most frequent Mycobacterium tuberculosis complex families in Mali (2006–2016) based on spoligotyping. Int J Mycobacteriol 6: 379386.
    [Google Scholar]
  11. Sharma A, Bloss E, Heilig CM, Click ES, 2016. Tuberculosis caused by Mycobacterium africanum, United States, 2004–2013. Emerg Infect Dis 22: 396403.
    [Google Scholar]
  12. Isea-Peña MC et al., 2012. Mycobacterium africanum, an emerging disease in high-income countries? Int J Tuberc Lung Dis 16: 14001404.
    [Google Scholar]
  13. Asare P et al., 2018. Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban west Africa. Int J Infect Dis 73: 3042.
    [Google Scholar]
  14. Bentley SD et al., 2012. The genome of Mycobacterium africanum west African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex. PLoS Negl Trop Dis 6: e1552.
    [Google Scholar]
  15. Gehre F, Otu J, DeRiemer K, de Sessions PF, Hibberd ML, Mulders W, Corrah T, de Jong BC, Antonio M, 2013. Deciphering the growth behaviour of Mycobacterium africanum. PLoS Negl Trop Dis 7: e2220.
    [Google Scholar]
  16. Ofori-Anyinam B et al., 2016. Impact of the Mycobaterium africanum west Africa 2 lineage on TB diagnostics in west Africa: decreased sensitivity of rapid identification tests in the Gambia. PLoS Negl Trop Dis 10: e0004801.
    [Google Scholar]
  17. Bastos HN, Osório NS, Gagneux S, Comas I, Saraiva M, 2017. The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes. Front Immunol 8: 1948.
    [Google Scholar]
  18. Asante-Poku A, Yeboah-Manu D, Otchere ID, Aboagye SY, Stucki D, Hattendorf J, Borrell S, Feldmann J, Danso E, Gagneux S, 2015. Mycobacterium africanum is associated with patient ethnicity in Ghana. PLoS Negl Trop Dis 9: e3370.
    [Google Scholar]
  19. de Jong BC et al., 2008. Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in the Gambia. J Infect Dis 198: 10371043.
    [Google Scholar]
  20. Tientcheu LD et al., 2016. Host immune responses differ between M. africanum- and M. tuberculosis-infected patients following standard anti-tuberculosis treatment. PLoS Negl Trop Dis 10: e0004701.
    [Google Scholar]
  21. Wiens KE et al., 2018. Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis. BMC Med 16: 196.
    [Google Scholar]
  22. Winglee K et al., 2016. Whole genome sequencing of Mycobacterium africanum strains from Mali provides insights into the mechanisms of geographic restriction. PLoS Negl Trop Dis 10: e0004332.
    [Google Scholar]
  23. Kone A et al., 2019. Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali. HLA 93: 2431.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.19-0264
Loading
/content/journals/10.4269/ajtmh.19-0264
Loading

Data & Media loading...

  • Received : 07 Apr 2019
  • Accepted : 09 Sep 2019
  • Published online : 11 Nov 2019
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error