1921
Volume 100, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A region-wide population-based post–mass drug administration (MDA) coverage survey was conducted 3 weeks following the 2016 trachoma MDA in Amhara, Ethiopia. The prevalence of self-reported side effects was assessed among those who self-reported receiving azithromycin. A total of 16,773 individuals from 5,129 households reported taking azithromycin during the 2016 MDA in Amhara. The regional prevalence of any self-reported side effect was 9.6% (95% CI: 8.3–11.2%) and ranged from 3.9% to 12.4% among the 10 zones. The most common reported side effects were abdominal pain (53.1%), nausea (21.7%), vomiting (12.8%), and diarrhea (12.5%). Side-effect prevalence among female members was higher than in male members (11.6% versus 7.6%; < 0.001) and increased with age. After an average of 8 years of annual MDA, the prevalence of self-reported side effects was less than 10% in this population.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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References

  1. WHO, 2010. Report of the 3rd Global Scientific Meeting on Trachoma. Baltimore, MD: WHO. [Google Scholar]
  2. Nash SD, 2018. Ocular Chlamydia trachomatis infection under the surgery, antibiotics, facial cleanliness, and environmental improvement strategy in Amhara, Ethiopia, 2011–2015. Clin Infect Dis 67: 18401846. [Google Scholar]
  3. Cromwell EA, King JD, McPherson S, Jip FN, Patterson AE, Mosher AW, Evans DS, Emerson PM, , 2013. Monitoring of mass distribution interventions for trachoma in Plateau state, Nigeria. PLoS Negl Trop Dis 7: e1995. [Google Scholar]
  4. Astale T, 2018. Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia. PLoS Negl Trop Dis 12: e0006270. [Google Scholar]
  5. Kisoka WJ, Simonsen PE, Malecela MN, Tersbol BP, Mushi DL, Meyrowitsch DW, , 2014. Factors influencing drug uptake during mass drug administration for control of lymphatic filariasis in rural and urban Tanzania. PLoS One 9: e109316. [Google Scholar]
  6. Cantey PT, Rao G, Rout J, Fox LM, , 2010. Predictors of compliance with a mass drug administration programme for lymphatic filariasis in Orissa state, India 2008. Trop Med Int Health 15: 224231. [Google Scholar]
  7. Nandha B, Sadanandane C, Jambulingam P, Das P, , 2007. Delivery strategy of mass annual single dose DEC administration to eliminate lymphatic filariasis in the urban areas of Pondicherry, south India: 5 years of experience. Filaria J 6: 7. [Google Scholar]
  8. Hussain MA, Sitha AK, Swain S, Kadam S, Pati S, , 2014. Mass drug administration for lymphatic filariasis elimination in a coastal state of India: a study on barriers to coverage and compliance. Infect Dis Poverty 3: 31. [Google Scholar]
  9. Ruuskanen O, , 2004. Safety and tolerability of azithromycin in pediatric infectious diseases: 2003 update. Pediatr Infect Dis J 23: S135S139. [Google Scholar]
  10. Ayele B, Gebre T, House JI, Zhou Z, McCulloch CE, Porco TC, Gaynor BD, Emerson PM, Lietman TM, Keenan JD, , 2011. Adverse events after mass azithromycin treatments for trachoma in Ethiopia. Am J Trop Med Hyg 85: 291294. [Google Scholar]
  11. Martin DH, Mroczkowski TF, Dalu ZA, McCarty J, Jones RB, Hopkins SJ, Johnson RB, , 1992. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The azithromycin for Chlamydial Infections Study Group. N Engl J Med 327: 921925. [Google Scholar]
  12. Langley JM, Halperin SA, Boucher FD, Smith B, , 2004. Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis. Pediatrics 114: e96e101. [Google Scholar]
  13. Cochereau I, Goldschmidt P, Goepogui A, Afghani T, Delval L, Pouliquen P, Bourcier T, Robert PY, , 2007. Efficacy and safety of short duration azithromycin eye drops versus azithromycin single oral dose for the treatment of trachoma in children: a randomised, controlled, double-masked clinical trial. Br J Ophthalmol 91: 667672. [Google Scholar]
  14. Solomon AW, Akudibillah J, Abugri P, Hagan M, Foster A, Bailey RL, Mabey DC, , 2001. Pilot study of the use of community volunteers to distribute azithromycin for trachoma control in Ghana. Bull World Health Organ 79: 814. [Google Scholar]
  15. Law C, Amsden GW, , 2004. Single-dose azithromycin for respiratory tract infections. Ann Pharmacother 38: 433439. [Google Scholar]
  16. West SK, West ES, Alemayehu W, Melese M, Munoz B, Imeru A, Worku A, Gaydos C, Meinert CL, Quinn T, , 2006. Single-dose azithromycin prevents trichiasis recurrence following surgery: randomized trial in Ethiopia. Arch Ophthalmol 124: 309314. [Google Scholar]
  17. Tabbara KF, Abu-el-Asrar A, al-Omar O, Choudhury AH, al-Faisal Z, , 1996. Single-dose azithromycin in the treatment of trachoma. A randomized, controlled study. Ophthalmology 103: 842846. [Google Scholar]
  18. Bailey RL, Arullendran P, Whittle HC, Mabey DC, , 1993. Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Lancet 342: 453456. [Google Scholar]
  19. Keenan JD, MORDOR Study Group , 2018. Azithromycin to reduce childhood mortality in sub-Saharan Africa. New Engl J Med 378: 15831592. [Google Scholar]
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  • Received : 26 Sep 2018
  • Accepted : 05 Dec 2018
  • Published online : 21 Jan 2019

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