1921
Volume 99, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract.

is a tick-borne intraerythrocytic parasite that is clinically and diagnostically similar to malaria parasite, conferring risk of misdiagnosis in areas where both parasites are endemic. Data on in humans in Africa are lacking, despite evidence that it is present in regional animal populations. Samples that were collected in November 2014 to July 2015 in Kilosa district, Tanzania, were evaluated for evidence of malaria and infection. Clinical data and laboratory samples (i.e., hemoglobin, rapid diagnostic testing [RDT] for malaria, peripheral blood smear, and dried blood spots) from a routine survey were available for analysis. Dried blood spots were tested using an investigational enzyme linked immunosorbent assay (ELISA) against . A total of 1,030 children aged 1 month to < 5 years were evaluated; 186 (18.1%) were malaria RDT positive, 180 (96.8%) of whom had peripheral smears reviewed; 70/180 (38.9%) were smear positive for parasites. The median (inter quartile range) and range of ELISA signal to cutoff (S/C) ratio was 0.10 (0.06–0.15) and 0.01–1.65, respectively; the S/C ratios were significantly higher in subjects ≥ 1 year as compared with those < 1 year old ( < 0.001). There was also a statistically significant association between a positive RDT for malaria and the S/C (median 0.09 versus 0.13 in RDT negative versus RDT positive, respectively; < 0.001). The highest S/C ratios were disproportionately clustered in a few hamlets. The findings suggest that may be present in Kilosa district, Tanzania. However, serological cross-reactivity and false positivity, notably between and spp., cannot be definitively excluded and have implications for testing in other settings.

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/content/journals/10.4269/ajtmh.18-0012
2018-07-05
2018-07-23
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  • Received : 08 Jan 2018
  • Accepted : 28 Feb 2018

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