Tetrachlorethylene, a New Anthelmintic

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  • Bureau of Animal Industry, United States Department of Agriculture, Washington, D. C.
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The comparatively high efficacy of chloroform (CHCl3) against hookworms, as administered in castor oil by Alessandrini and as used in Hermann's mixtures by others in clinical experience, was confirmed in critical tests on dogs by Hall and Foster. With this clue to the efficacy of chlorine derivatives, Hall tested the closely related compound, carbon tetrachloride (CCl4) and found an increased efficacy, apparently associated with the higher chlorine content, a possibility hinted at by Caius and Mhaskar in a paper published simultaneously with Hall's first paper. In the past three years of its use in medicine carbon tetrachloride has come into increasing vogue in the treatment of human hookworm disease, and recent papers by Bais and by Giglioli give impressive evidence of its superiority to other drugs and to its economic value.