Studies from the Institute for Medical Research, Kuala Lumpur, Federated Malay States, No. 18. Notes on the Treatment of Malaria with the Alkaloids of Cinchona

By William Fletcher, M. D. Camb., Bacteriologist, Institute for Medical Research, Kuala Lumpur. Publishers, John Bale, Sons & Danielsson, Ltd., Oxford House, London

Lewis B. Bates Ancon Hospital, Ancon, Canal Zone

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This book is a monograph on the treatment of malaria. It has nine chapters and ninety-one pages. Each chapter treats of a distinct phase of the subject and a perusal of the chapter titles given below will give a good idea of the scope of the work. The first impression gained in reading this book is that the author is giving the reader the results of his own personal experience and that although references are frequent the subject matter is true first hand knowledge.

Chapter I: Cinchona Febrifuge. This is evidently a proprietary article, considerably used throughout the British dependencies and without legally defined composition. The author pleads for its standardization.

Chapter II: The Relative Merits of the different Alkaloids of Cinchona in Malaria. “In doses of ten grains twice a day, the four crystallizable alkloids, quinine, quinidine, cinchonine, and cinchonidine, appeared to be of equal value in bringing about the disappearance of malarial parasites, in patients weighing about 100 pounds.”

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