Observations on the Treatment of Human Teniasis with Quinacrine Hydrochloride (Atabrine)

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  1. 1.Quinacrine (Atabrine dihydrochloride) orally in 34 patients with Taenia saginata infection produced expulsion of the worm within 1 to 2 hours after the saline purge. The worm was expelled alive in all instances. In 21 cases the worm and scolex were identified, while in only 13 cases the scolex could not be identified. In all of these cases repeated follow up stool examinations have been negative.
  2. 2.Quinacrine orally in the treatment of Hymenolepis nana infection was relatively ineffective, causing the expulsion of the worm in only two instances. The stools were not rendered free of ova after treatment.
  3. 3.No toxic effects were noticed in any patient in this series sufficient to warrant hospitalization for treatment.

Author Notes

Former lecturer Parasitology and Tropical Medicine, Stritch School of Medicine, Loyola University, Chicago, Illinois. Consulting Parasitologist, Hospital General San Felipe, Tegucigalpa, D.C., Honduras.