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September 27, 1949

Dr. Mark F. Boyd, Editor,

The American Journal of Tropical Medicine

615 East Sixth Avenue

Tallahassee, Florida.

This is in reference to the paper by Berberian and Dennis in the July 1949 issue of the Journal, entitled “Chloroquine Diphosphate and Malaria Splenomegaly.”

The confusion of terms in referring to spleen measurements in malaria is unfortunate. Hackett (Jour. Nat. Mal. Soc. 3: 121–133, 1944) proposes a standardization of terms when referring to averages of spleen sizes:

AES (Average Enlarged Spleen) equals the sum of the products of the weighted groups divided by the number with enlarged spleens. AES can never be less than 1.0 nor can it exceed 5.0.

AS (Average Spleen) equals sum of products of the weighted groups divided by the total number of children examined. AS can vary from 0.0 to 5.0.

Russell, Manwell and West (Practical Malariology p. 391–392) do not recognize the AS as defined above and their AES is equivalent to the AS of Hackett.