Infantile Cirrhosis of the Liver

By S. K. Mukherji. Published by the Indian Record Book Department, Calcutta

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  • Medical Research Division, Chemical Warfare Service United States Army, Edgewood Arsenal, Md.
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This interesting little book of 95 pages, deals with a condition that is claimed to occur only in India and concerning which almost nothing is known. Infantile biliary cirrhosis is barely mentioned in a few text books of Tropical Medicine, yet according to the author's statistics it has been responsible for from 500 to 700 deaths annually in Calcutta alone.

The period of greatest susceptibility is from six to twenty-four months of age. Infantile cirrhosis is diagnosed by: (1) Absence of all known etiological factors; (2) history of infantile liver in other children of the mother; (3) age, six to twenty-four months; (4) insidious onset; (5) enlargement of liver followed by contraction; (6) jaundice; (7) fever for which no other cause can be found; (8) clayey stools; (9) persistent constipation.

Both liver and spleen are enlarged. The liver presents the typical appearance of hypertrophic biliary cirrhosis both in the gross and in sections.