The protective properties of aureomycin hydrochloride, sulfamerazine, sodium sulfathiazole or 4,4′-diamino diphenyl sulfone have been demonstrated and compared by oral administration to mice inoculated with toxoplasma.
The sulfone provided a greater degree of protection than any of the others tested. Aureomycin and sulfathiazole afforded approximately equal protection while sulfamerazine was the least effective.
Since para-aminobenzoic acid failed to counteract the protective effect of aureomycin it appears that the mode of action of this antibiotic in preventing the death of toxoplasma-infected mice is different than that of sodium sulfathiazole or 4,4′-diamino diphenyl sulfone.
Department of Microbiology, School of Medicine, Indiana University, Indianapolis, Indiana.