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During an epidemic wave of yellow fever, which entered the western part of the State of Minas Gerais in 1935, virus spread throughout the numerous small discontinuous forest patches which characterize this area. These forest patches are uninhabited by humans but have a permanent population of cebus monkeys. Evidence is presented which indicates that the virus probably persisted in these isolated forests only for a short time after the cessation of human infections. There is no evidence that virus is active in this area at the present time.