Phthalylsulfacetimide (Thalamyd) in Cholera

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Since cholera is characterized by acute salt and water depletion, and severe general toxemia, the therapeutic problems are to restore fluid and salt, and to eradicate the infecting organism. In addition, special measures are being employed to protect body systems against the toxemia, such as the use of testosterone for its effect on the kidney (8).

In 1947 cholera appeared in Egypt for the first time since 1902, reaching epidemic proportions during September and forming a total of 21,661 cases by the end of December (14). The mortality was 10,696 or 49.4 per cent. During this epidemic, we were able to treat more than one hundred patients with phthalylsulfacetimide, but, owing to well known difficulties prevailing in any cholera epidemic, we have complete records for only forty. In this series of forty cases, there was one death, or 2.5 per cent. For reasons which will be made plain, we do not stress comparative mortality figures, nor insist upon the validity of statistics purporting to evalute a drug during a raging epidemic.

Author Notes

From the College of Physicians and Surgeons, Columbia University, New York, N. Y.

Clinical Research Division, Schering Corporation, Bloomfield, New Jersey.