Action of Some Alkylhydroxybenzenes on Pig Ascaris in Vitro

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  • Department of Laboratories, Henry Ford Hospital, Detroit, Michigan

An extensive and thorough study of the anthelmintic properties of alkylhy-droxybenzenes has been made by Lamson and his associates (1–4). These authors systematically tested more than 150 different compounds and initiated the therapeutic use of hexylresorcinol in certain helminth infestations. It has been shown (5) that the introduction of halogen into hydroxybenzenes enhances their antiseptic potency. Hartman and Schelling (6) have previously studied a number of new halogen-substituted hydroxybenzenes for their antiseptic properties. Among those substances, there were some with very high germicidal activity. It therefore seemed of interest to test these compounds also for their anthelmintic properties.

METHODS Tests were run according to the in vitro method of Lamson and Brown (7). Briefly, this method consists of exposing well-washed worms to the drug in 1:1000 saline suspension for varying periods of time with constant stirring. After keeping the worms in physiological saline in the incubator overnight, they are then tested for motility by dropping them into water at 60° C.