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This elaborate document is presented as the final report of the Malaria Research Service of the British Guiana Medical Department. Hydrographical conditions in the settled coastland areas are peculiarly favorable to the mosquitoes, especially anophelines, and mosquito-borne diseases have always afforded the most salient public health problems in the colony. Since the perpetuation of these conditions is intimately related to, and imperatively required for the maintenance of the colony's economy, there was little likelihood that classical measures of control could be employed to make any substantial contribution toward their elimination. It was fortunate that previous to the very opportune introduction of DDT, intensive studies of malaria had been prosecuted for a decade, at first by Dr. Giglioli himself under the auspices of the Sugar Producer's Association, later by Drs. Giglioli and Bevier under a tripartite program of cooperation extended to include the Colonial Government and the Rockefeller Foundation, so that the scope and character of the malaria problem had been well defined.