Pathology of Kala-Azar

Report of a Case

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An autopsy protocol of a native East Indian dying with Kala-Azar in America is described. The hazard inherent with splenic puncture is illustrated. Sternal puncture makes the former procedure unnecessary. Ordinary hematoxylin-eosin stain on formalin fixed tissue permits illustration of the Leishman-Donovan bodies. A “clasmatocyte tissue” response is the underlying pathologic response to the parasite even though parasites cannot be readily demonstrated in the cell. In addition to splenomegaly and hepatomegaly, bronchopneumonia, ulceration of the bowel and brain tissue changes were found.

Author Notes

Present address: Veterans Administration Center, Wood, Wisconsin.

Published with the permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinions expressed or the conclusions drawn by the author.

Microphotographs made through the kindness of Dr. Stanley Rhea, Tulane University Medical School, New Orleans, Louisiana.