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Field trials in British Guiana in 1946 showed that metachloridine at doses of 1 to 2 grams weekly, divided into 2, 3 or 5 parts, completely suppressed natural infections of P. malariae and partially suppressed parasitemia with P. falciparum. Limited data indicate good suppression of P. vivax. No toxicity was seen during the treatment period of 6 months. Lower doses should be tried to determine the minimum effective dose for the suppression of P. malariae and higher doses should be tried for the same purpose in infections with P. falciparum. The ability of metachloridine to suppress clinical symptoms of infections with P. falciparum should be determined.
Resident Physician, Berbice Co. Ltd., Kwakwani, British Guiana.
Leader, Parasitology Group, Chemotherapy Division, Stamford Research Laboratories of the American Cyanamid Company, Stamford, Connecticut.