We wish to record the results of certain experiments performed to ascertain the degree of protection against the acquirement of malaria infections afforded by various dosages of quinacrine hydrochloride (atabrine) when administered to patients inoculated with one or more species of malaria parasites at varying levels of inoculation intensity.
The drug employed was furnished through the courtesy of the Winthrop Chemical Company, and was received in original 1000-tablet containers bearing the identifying number BTO27.
Patients were inoculated by the application of various lots of insectary-reared Anopheles quadrimaculatus which had been experimentally infected with Plasmodium vivax, McCoy strain, or Plasmodium falciparum, Costa strain. After the mosquitoes had been used, their salivary glands were removed by dissection and examined for the presence of sporozoites.
The patients were white adult males presumably susceptible to malaria infections. They were kept under observation and daily blood smears were taken, for a period of at least six months subsequent to the termination of the course of quinacrine.