Criteria of Immunity and Susceptibility in Naturally Induced Vivax Malaria Infections

Mark F. BoydStation for Malaria Research, Tallahassee, Florida

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The patient population of the Florida State Hospital, is, as might be expected in a state that has attracted much immigration during the last two decades, highly cosmopolitan, and we presume that the neurosyphilitic patients for whom malaria therapy is prescribed reflect this characteristic. Be that as it may, we find that the white patients inoculated with vivax malaria show great variation in the character and duration of the subsequent infection they experience. Assuming that these variations may be attributable to varying degrees of prior immunity or susceptibility, it is desirable to analyze the data available which may throw light on this assumption, as well as ascertain the possible limits for the duration of the primary attack in a susceptible person.

The familiar chronicity of vivax infections, plus the frequent interruptions of clinical activity by one or more remissions of variable and often considerable duration, make it difficult to determine what periods of clinical activity may be properly referable to the primary attack, and what should properly be regarded as secondary periods of activity.