Synthetic remedies present one great defect which has interfered greatly in their use and development. This is the toxic reaction which has so often been observed before their application has been thoroughly studied. These reactions occur very frequently in localities where proper antidotal steps cannot be taken. This has been noted in recent years in the use of the important drugs, sulfanilimide and sulfapyridin.
When atabrine was first used in the treatment of malaria alarming reports of toxic reactions were received from all sides. These reports were of such a character that great difficulty was experienced in obtaining the consent of physicians and patients to its administration.
As the U. S. Army contemplated using this drug extensively a study of reports of reactions was made and a detailed report covering all cases in which atabrine was administered was required. These reports were very favorable and the increasing use of the drug confirmed them.