Immunization Against Yellow Fever with a Consideration of the Effects of a Virulent Neurotropic Strain on the Central Nervous System of Monkeys

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  • Department of Comparative Pathology and Tropical Medicine, Schools of Medicine and Public Health, Harvard University, Boston, Mass.


The effect of small amounts of a virulent strain of neurotropic yellow fever on the central nervous system of rhesus monkeys (Macaca mulatta) was tested by direct injection into the cerebrum, into the great cistern, and also by subcutaneous injection with gross traumatization of the brain. Some animals developed a fatal encephalitis, some developed immune bodies in their serum and some remained normal with the probability that the inoculum for at least part of these contained no virus. There were no recoveries among the monkeys in which definite signs of encephalitis appeared. Accidents of vaccination in man have occurred in any form of technique in which living virus is employed. Thus far, the patients have shown symptoms of meningitis, encephalitis or myelitis followed by complete recovery without sequellae.