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The observations discussed indicate that well-fixed subspecific varieties, strains, or races of two species at least of the human plasmodia are discernible immunologically. These differences in some cases are correlated with clear-cut variations in the characteristics of the clinical infection. Meager observations suggest that some strains may have a localized habitat or geographical distribution. In some instances this localization may represent an extreme degree of adaptation to species or races of the definitive hosts of the same faunal region.