The Infection of Mature and Immature Erythrocytes by Plasmodium Falciparum and Plasmodium Malariae

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  • Station for Malaria Research, Tallahassee, Florida
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There have been presented findings obtained from the study of serial reticulocyte preparations of the peripheral blood made during described periods in three falciparum and two malariae infections.

The total numbers of mature erythrocytes infected with P. falciparum constantly exceeded the total numbers of parasitized reticulocytes. Infected mature erythrocytes were found on all occasions; infected reticulocytes were observed in only 70 per cent of instances. The two types of host cell alternated irregularly in exhibiting the higher rate of infection. Correlations between the findings and the stage of the disease process were not discernible.

P. malariae, on all occasions, was found in mature erythrocytes in both greater absolute and relative numbers than in reticulocytes. The incidence of infection of the immature erythrocytes by this parasite was extremely low.