The Production of Encephalitis in Macacus Rhesus with Viscerotropic Yellow Fever Virus

H. A. Penna Laboratory of the Yellow Fever Service at Bahia, Brazil

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Summary and Conclusions

  1. 1. By a special method consisting in the inoculation of yellow fever immune serum by the intraperitoneal route followed by intracerebral inoculation of viscerotropic yellow fever virus the writer was able to produce encephalitis in Macacus rhesus.
  2. 2. Serial intracerebral subinoculations with this virus, using the same technique, in two series of rhesus monkeys led to a modification of the virus in one of the series, which was first noted in the thirty-fifth passage.
  3. 3. Brain to brain transfers were carried to the eighty-fifth passage. The changes obtained in the virus appear to be sufficiently marked to justify for the modified strain the name of “neurotropic” although it is believed that it is not entirely comparable to the mouse-brain-adapted virus of the same number of passages.
  4. 4. Encephalitis due to inoculation with viscerotropic yellow fever virus was not found to differ clinically or pathologically from the encephalitis produced in monkeys by inoculation with mouse-brain-adapted yellow fever virus.

Author Notes